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Gene symbol or metabolite | Cell culture | Reference | Examined force applied | Gene expression | Substance secretion |
Duration (h) | Magnitude (g/cm2) | Increase/decrease/no change | Change in relation to force duration (h) | Change in relation to force magnitude (g/cm2) | Increase/decrease/no change | Change in relation to force duration (h) | Change in relation to force magnitude (g/cm2) |
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PGE2 | 2D | Benjakul et al. in press [17] | 48 | 1.5 | na | | | Increase (qPCR: GAPDH) | 48 | 1.5 |
Jin et al. 2015 [18] | 0; 0.5; 3; 6; 12 | 2.0 | na | | | Increase (ELISA) | 12 | 2.0 |
Kang et al. 2010 [19] | 0.5; 2; 6; 24; 48 | 2.0 | na | | | Increase (ELISA) | 48 | 2.0 |
Kanzaki et al. 2002 [20] | 0.5; 1.5; 6; 24; 48 (+ELISA: 60) | 0.5; 1.0; 2.0; 3.0; 4.0 (ELISA: 2.0) | na | | | Increase (ELISA) | 60 | 2.0 |
Kirschneck et al. 2015 [21] | 24 | 2.0 | na | | | Not explicitly stated (ELISA) | | |
Liu et al. 2006 [22] | 48 | 2.0 | na | | | Increase (ELISA) | 48 | 2.0 |
Mayahara et al. 2007 [23] | 3; 6; 12; 24; 48 | 2 | na | | | Increase (ELISA) | 48 | 2 |
Premaraj et al. 2013 [24] | 0.5; 1; 3; 6 | 5.0 | na | | | Increase (ELISA) | 1 | 5.0 |
Proff et al. 2014 [9] | 24 | 2 | na | | | Increase (ELISA) | 24 | 2 |
Römer et al. 2013 [25] | 24 | 2 | na | | | Increase (ELISA) | 24 | 2 |
3D (Coll. gel) | de Araujo et al. 2007 [26] | 3; 12; 24; 48; 72 | 6.0 | | | | Increase (EIA) | 72 | 6.0 |
3D (PLGA) | Li et al. 2016 [27] | 6; 24; 72 | 5.0; 15.0; 25.0 | na | | | Increase (ELISA) | 24 | 15.0…25.0 |
Yi et al. 2016 [28] | 24 | 25.0 | | | | Increase (ELISA) | 24 | 25.0 |
|
PTGS2 | 2D | Jin et al. 2015 [18] | 0; 0.5; 3; 6; 12 | 2.0 | Increase (qPCR: GAPDH) | 12 | 2.0 | | | |
Kang et al. 2010 [19] | 0.5; 2; 6; 24; 48 | 2.0 | Increase (qPCR: GAPDH) | 48 | | | | |
Kanzaki et al. 2002 [20] | 0.5; 1.5; 6; 24; 48 | 0.5; 1.0; 2.0; 3.0; 4.0 | Increase (sqPCR: ACTNB) | 6 | 2.0 | | | |
Kirschneck et al. 2015 [21] | 24 | 2.0 | Increase (qPCR: POL2RA) | 24 | 2.0 | | | |
Liu et al. 2006 [22] | 48 | 2.0 | Increase (sqPCR: ACTNB) | 48 | 2.0 | | | |
Mayahara et al. 2007 [23] | 3; 6; 12; 24; 48 | 2 | Increase (qPCR: GAPDH) | 48 | 2 | | | |
Mayahara et al. 2010 [29] | 3; 6; 12; 24; 48 | 2.0 | Increase (qPCR: GAPDH) | 48 | 2 | | | |
Premaraj et al. 2013 [24] | 6 | 0.2; 2.2; 5.0 | nd | | | Increase (WB) | 6 | 5.0 |
Proff et al. 2014 [9] | 24 | 2 | Increase (qPCR: POL2RA) | 24 | 2 | Increase (WB) | 24 | 2 |
Römer et al. 2013 [25] | 24 | 2 | Increase (qPCR: POL2RA) | 24 | 2 | | | |
Wongkhantee et al. 2007 [30] | 24 | 0; 1.25; 2.5 | Increase (sqPCR: GAPDH) | 24 | 2.5 | | | |
3D (Coll. gel) | de Araujo et al. 2007 [26] | 1; 3; 6; 12; 24; 48; 72 | 3.6; 6.0; 7.1; 9.5 | Increase (sqPCR: GAPDH) | 6 | 7.1 | | | |
3D (PLGA) | Li et al. 2016 [31] | 6; 24; 72 | 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | | | |
Li et al. 2013 [32] | 6; 24; 72 | 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | | | |
Li et al. 2016 [27] | 6; 24; 72 | 5.0; 15.0; 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | | | |
Li et al. 2011 [33] | 6 | 5; 15; 25; 35 | Increase (qPCR: GAPDH) | 6 | 35.0 | | | |
Yi et al. 2016 [28] | 24 | 25.0 | Increase (qPCR: GAPDH) | 24 | 25.0 | Increase (WB) | 24 | 25.0 |
|
TNFRSF11B | 2D | Benjakul et al. in press [17] | 48 | 1.5 | No change (qPCR: GAPDH) | | | No change | | |
Jin et al. 2015 [18] | 0; 0.5; 3; 6; 12 | 2.0 | No change (qPCR: GAPDH) | | | | | |
Kanzaki et al. 2002 [20] | 0.5; 1.5; 6; 24; 48 | 0.5; 1.0; 2.0; 3.0; 4.0 | No change (sqPCR: ACTNB) | | | | | |
Kim et al. 2013 [8] | 0.5; 2; 6; 24; 48 | 2.0 | Transitory downregulated. (qPCR: GAPDH) | 6 | 2.0 | Transitory downregulation (ELISA) | 6 | 2.0 |
Kirschneck et al. 2015 [21] | 24 | 2.0 | No change (qPCR: POL2RA) | | | | | |
Lee et al. 2015 [34] | 0; 2; 4; 8; 24; 48 | 2.5 | No change (qPCR: ACTNB) | | | | | |
Liu et al. 2017 [35] | 6; 12; 24 | 0.5; 1.0; 1.5 | nd | | | Decrease (WB) | n. g. | 1.5 |
Luckprom et al. 2011 [36] | 2; 4 | 2.5 | No change (sqPCR: GAPDH) | | | | | |
Mitsuhashi et al. 2011 [37] | 1; 3; 6; 9; 12; 24 | 4.0 | No change (qPCR: ACTNB) | | | | | |
Nakajima et al. 2008 [38] | 0; 1; 3; 6; 9; 12; 24 | 0.5; 1.0; 2.0; 3.0; 4.0 | nd | | | Increase (ELISA) | 24 | 0.5 |
Nishijima et al. 2006 [39] | 48 | 0; 0.5; 1.0; 2.0; 3.0 | nd | | | Decrease (ELISA) | 48 | 2.0 |
Römer et al. 2013 [25] | 24 | 2 | No change (qPCR: RNA-polymerase-2-polypeptide A) | | | | | |
Yamada et al. 2013 [40] | 12 | 4.0 | Decrease (qPCR: GAPDH) | 12 | 4.0 | Decrease (ELISA) | 12 | 4.0 |
Yamaguchi et al. 2006 [41] | 0; 3; 6; 9; 12; 24; 48 | 0.5; 1.0; 2.0; 3.0 | n. d. | | | Decrease (ELISA) | 12…48 | 2.0 |
3D (Coll. gel) | Kaku et al. 2016 [42] | 12; 24 | 0.5; 1.0; 2.0 | Increase (qPCR: GAPDH) | 12 | 1.0 | | | |
3D (PLLA modif.) | Liao et al. 2016 [14] | 1 d; 3 d; 7 d; 14 d | 5.0; 15.0; 25.0; 35.0 | No change (qPCR: GAPDH) | | | | | |
3D (PLGA) | Jianru et al. 2015 [43] | 3; 6; 12 (WB: 12) | 25.0 | Decrease followed by increase (qPCR: GAPDH) | 3 (decrease) 12 (increase) | 25.0 | Increase (WB) | 12 | 25.0 |
Li et al. 2016 [31] | 6; 24; 72 | 25.0 | Decrease followed by Increase (qPCR: GAPDH) | 6 (decrease) 72 (increase) | 25.0 | | | |
Li et al. 2016 [27] | 6; 24; 72 | 5.0; 15.0; 25.0 | Decrease followed by increase (qPCR: GAPDH) | 6 (decrease) 72 (increase) | 15.0 (decrease) 25.0 (increase) | Decrease followed by Increase (qPCR: GAPDH) | 6 (decrease) 72 (increase) | 25.0 (decrease) 25.0 (increase) |
Li et al. 2011 [33] | 6; 24; 72 | 25 | Decrease followed by increase (qPCR: GAPDH) | 6 (decrease) 72 (increase) | 25.0 | | | |
Yi et al. 2016 [28] | 24 | 25.0 | Decrease (qPCR: GAPDH) | 24 | 25.0 | No change (WB) | | |
|
TNFSF11 | 2D | Benjakul et al. in press [17] | 48 | 1.5 | Increase (qPCR: GAPDH) | 48 | 1.5 | Increase (qPCR: GAPDH) | 48 | 1.5 |
Jin et al. 2015 [18] | 0; 0.5; 3; 6; 12 | 2.0 | Increase (qPCR: GAPDH) | 12 | 2.0 | | | |
Kang et al. 2013 [44] | 2; 48 | 2.0 | Increase (qPCR: GAPDH) | 48 | 2.0 | | | |
Kanzaki et al. 2002 [20] | 0.5; 1.5; 6; 24; 48 | 0.5; 1.0; 2.0; 3.0; 4.0 | Increase (sqPCR: ACTNB) | 48 | 2.0 | Increase (WB): 40-kDa+ 55-kDa | 48 | 2.0 |
Kikuta et al. 2015 [45] | 1; 3; 6; 9; 12; 24 (+ELISA: 48) | 4.0 | Increase (qPCR: GAPDH) | 12 | 4.0 | Increase (ELISA) | 24 | 4.0 |
Kim et al. 2013 [8] | 0.5; 2; 6; 24; 48 | 2.0 ++ | Increase (qPCR: GAPDH) | 24 | 2.0 | Increase (ELISA) | 48 | 2.0 |
Kirschneck et al. 2015 [21] | 24 | 2.0 | Increase (qPCR: POL2RA) | 24 | 2.0 | | | |
Lee et al. 2015 [34] | 0; 2; 4; 8; 24; 48 | 2.5 | Increase (qPCR: ACTNB) | 24 | 2.5 | | | |
Liu et al. 2017 [35] | 6, 12, 24 | 0.5; 1.0; 1.5 | nd | | | Increase (WB: GAPDH) | ng | 1.5 |
Liu et al. 2006 [22] | 48 | 2.0 | Increase (sqPCR: ACTNB) | 48 | 2.0 | | | |
Luckprom et al. 2011 [36] | 2; 4 | 2.5 | Increase (sqPCR: GAPDH) | 2 | 2.5 | Increase (WB) | 4 | 2.5 |
Mitsuhashi et al. 2011 [37] | 1; 3; 6; 9; 12; 24 | 4.0 | Temporary increase (qPCR: ACTNB) | 6…9 | 4.0 | | | |
Nakajima et al. 2008 [38] | 0; 1; 3; 6; 9; 12; 24 | 0.5; 1.0; 2.0; 3.0; 4.0 | nd | | | Increase (ELISA) | 24 | 4.0 |
Nishijima et al. 2006 [39] | 48 | 0; 0.5; 1.0; 2.0; 3.0 | nd | | | Increase (ELISA) | 12…48 | 2.0 |
Römer et al. 2013 [25] | 24 | 2 | Increase (qPCR: RNA-polymerase-2-polypeptide A) | 24 | 2 | | | |
Wongkhantee et al. 2007 [30] | 24 | 0; 1.25; 2.5 | Increase (sqPCR: GAPDH) | 24 | 2.5 | Increase (WB; ACTNB) | 24 | 2.5 |
Yamada et al. 2013 [40] | 12 | 4.0 | Increase (qPCR: GAPDH) | 12 | 4.0 | Increase (ELISA) | 12 | 4.0 |
Yamaguchi et al. 2006 [41] | 0; 3; 6; 9; 12; 24; 48 | 0.5; 1.0; 2.0; 3.0 | nd | | | Increase (ELISA): sRANKL Increase (WB) | 12…48 12 | 2.0 2.0 |
3D (Coll. gel) | Kang et al. 2013 [44] | 2; 48 | 2.0 | Increase (qPCR: GAPDH) | 2 | 2.0 | | | |
3D (PLLA modif.) | Liao et al. 2016 [14] | 1 d; 3 d; 7 d; 14 d | 5.0; 15.0; 25.0; 35.0 | Increase (qPCR: GAPDH) | Day 14 | 35.0 | | | |
3D (PLGA) | Jianru et al. 2015 [43] | 3; 6; 12 (WB: 12) | 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | Increase (WB) | 12 | 25.0 |
Li et al. 2016 [31] | 6; 24; 72 | 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | | | |
Li et al. 2016 [27] | 6; 24; 72 | 5.0; 15.0; 25.0 | Increase (qPCR: GAPDH) | 6 | 25.0 | Decrease (ELISA) | 72 | 25.0 |
Li et al. 2011 [33] | 6; 24; 72 | 5; 15; 25; 35 | Increase (qPCR: GAPDH) Increase followed by no change (qPCR: GAPDH) | 6 6 (increase) 72 (no change) | 25…35.0 25 25 | | | |
Yi et al. 2016 [28] | 24 | 25.0 | Increase (qPCR: GAPDH) | 24 | 25.0 | Increase (WB) | 24 | 25.0 |
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