Stem Cells International / 2018 / Article / Tab 2 / Review Article
In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic ReviewTable 2 KEGG pathways relevant for OTM with false discovery rates below 1.00E − 05 derived from STRING analysis using the set of examined genes from human periodontal ligament cells (“hPDLC list”; top panel) and human bone and bone-related cells and cell lines (“hOB list”; bottom panel). “X”, gene involved in that specific pathway.
(a)
KEGG ID 4060 4668 4510 4620 4370 4062 4380 4010 4064 KEGG name Cytokine-cytokine receptor interaction TNF signaling pathway Focal adhesion Toll-like receptor signaling pathway VEGF signaling pathway Chemokine signaling pathway Osteoclast differentiation MAPK signaling pathway NF-kappa B signaling pathway False discovery rate 2.62E –15 2.06E –12 3.90E –11 2.04E –09 9.47E –08 1.33E –07 2.29E –07 1.42E –06 1.86E –05 ADRB2 AKT1 X X X X X X X ALPL BGLAP CBS CCL2 X X X CCL3 X X X CCL5 X X X X CCND1 X CCR5 X X CDH11 COL1A1 X COL3A1 X COL5A1 X CSF1 X X X CTNNB1 X CTSB CTSL CXCL8 (= IL8) X X X X FGF2 X GJA1 GSK3b X X HMGB1 HSP90AA1 HSPA4 HSPB1 X X IGF1 X IL17A X IL1B X X X X X X IL6 X X X JAG1 X LGALS3BP MMP13 MMP3 X PIEZO1 PLA2G4A X X POSTN PTGS1 PTGS2 X X X PTK2 X X X RUNX2 SPP1 X X TGFB1 X X TGFB3 X X X TNF X X X X X X TNFRSF11B X X TNFSF11 X X X VEGFA X X X
(b)
KEGG ID 4350 4060 4064 4390 4668 4210 4380 4620 4066 KEGG name TGF-beta signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Hippo signaling pathway TNF signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway HIF-1 signaling pathway False discovery rate 8.33E –23 2.37E –21 8.32E –11 5.07E –09 1.01E –08 6.26E –08 1.02E –05 6.79E –05 7.16E –05 ACVR1 X X ACVR2A X X ACVR2B X X ALPL BAX X BCL2 X X X BGLAP BMP2 X X X BMP4 X X BMP6 X X BMP7 X X X BMPR1A X X X BMPR1B X X X BMPR2 X X X Casp3 X X CHRD X CXCR1 X FST X GREM1 IBSP IL11 X IL11RA IL1b X X X X X X IL1r1 X X X X IL6 X X X X IL6R X X IL8 X X X X MKI67 MMP1 MMP13 MMP14 MMP2 MMP3 NOG X PLAT PLAU X PTGS2 X RUNX2 SERPINE1 X X SMAD1 X X SP7 SPP1 X X TIMP1 X TIMP2 TIMP3 TIMP4 TNF X X X X X X X TNFRSF11B X TNFRSF1A X X X X TNFSF11 X X ZNF354C
