Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

<div>Protocol for animal experiments. (a) Experimental protocol for HFD-induced NASH model. Rats received HFD for four weeks. AMSC-EVs (15 <i>μ</i>g/kg) were infused intravenously (i.v.) at weeks 3 and 4. All rats were sacrificed at week 5. (b) Experimental protocol for CCl<sub>4</sub>-induced liver fibrosis. Rats received intraperitoneal (i.p.) injection 2 mL/kg CCl<sub>4</sub> in 50% olive oil twice a week for six weeks. AMSC-EVs (20 <i>μ</i>g/kg) were infused intravenously at week 3. All rats were sacrificed at week 7. HFD: high-fat diet; NASH: nonalcoholic steatohepatitis; AMSC: amnion-derived mesenchymal stem cell; EV: extracellular vesicle; CCl<sub>4</sub>: carbon tetrachloride.</div>

Stem Cells International

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Figure 1

Figure 1: Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats 