Research Article
Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats
Figure 3
Effect of AMSC-EVs in rats with HFD-induced steatohepatitis. (a) Gross appearance of the dissected liver. (b) Hematoxylin and eosin staining. (c) Expression of CD68. (d–k) Quantitative reverse transcription polymerase reaction for Tnf-α, Il-1β, Il-6, Mcp-1, Tgf-β, Cd68, Cd11c, and Cd163, respectively. Data are presented as means ± standard deviation. , versus control, , versus HFD. Scale bar, 200 μm. AMSC: amnion-derived mesenchymal stem cell; EV: extracellular vesicle; HFD: high-fat diet; Tnf-α: tumor necrosis factor-α; Il: interleukin; Mcp-1: monocyte chemoattractant protein-1; Tgf-β: transforming growth factor-β.
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