The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Figure 1

Myeloid progenitor and hematopoietic stem cell populations are changed in Flt3-ITD mice. Analysis of hematopoietic stem cell (HSC) and multipotent progenitor (MPP) subpopulations within the Lin⁻Sca-1⁺Kit⁺ (LSK) population, as well as myeloid progenitors including pre-GM and granulocytic myeloid progenitors (GMPs), in the bone marrow of Flt3-ITD and wild-type (WT) mice, was performed using a staining procedure including endoglin and the SLAM receptor CD150.