The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Figure 5

Small molecule inhibitor, PKC412, modulates the expression of Myc network genes in human MV4-11 cells. The human Flt3-ITD mutated leukemia cell line, MV4-11, was treated with the Flt3-inhibitor PKC412 at two different concentrations (0.1 mM and 1 mM) for 15 minutes. Expression analysis of the Myc network genes was carried out with RT-Q-PCR. ND: not detected.