Human Endometrial Regenerative Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis in Mice

Figure 4

ERCs attenuate lung fibrosis by reducing the expression of vital factor TGF-β. Immunohistochemical result of transforming growth factor-beta (TGF-β) (×200 magnification); yellowish-brown staining signifies positive staining of TGF-β. In the untreated group, TGF-β expressed abundantly and mainly deposited on proliferating inflammatory cells and fibrous tissues, while in the ERC-treated group, it can be seen that the TGF-β expression is reduced, which is similar to the sham control group. ERCs: endometrial regenerative cells; TGF-β: transforming growth factor-β.