Human Endometrial Regenerative Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis in Mice

Figure 7

ERCs attenuate pulmonary fibrosis by upregulating antiapoptotic and antifibrotic factors in the lungs. RT-qPCR was performed to detect the relative expression levels of mRNAs of (a) Bax, (b) Bcl-2, (c) HGF, and (d) MMP-9. Data revealed that ERCs upregulate the expression of HGF, MMP-9, and Bcl-2, while downregulating the expression of Bax. Values were normalized to β-actin. Bar graphs represent mean ± SEM of three separate experiments. values were determined by Independent-samples t test. Data shown are representative of three separate experiments performed. ( versus the untreated group, ). ERCs: endometrial regenerative cells; RT-qPCR: quantitative real-time polymerase chain reaction; Bax: bcl-2-associated x protein; Bcl-2: b cell lymphoma-2; HGF: hepatocyte growth factor; MMP-9: matrix metalloproteinase 9.

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