Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma
Table 2
DAVID annotation of DEGs in SCEC group.
Database
Name
Count
Benjamini value
KEGG
DNA replication
19
8.88E − 10
Cell cycle
33
8.61E − 09
P53 signaling pathway
19
4.80E − 05
Progesterone-mediated oocyte maturation
18
0.00457
Base excision repair
11
0.00419
Oocyte meiosis
20
0.00790
REACTOME
Cell cycle, mitotic
100
3.47E − 36
DNA replication
29
7.19E − 08
DNA repair
22
0.00173
Cell cycle checkpoints
23
0.00184
Telomere maintenance
14
0.00713
PANTHER
P53 pathway
22
0.0456
GO BP (TOP10)
M phase
99
3.91E − 28
M phase of mitotic cell cycle
78
1.97E − 26
Mitosis
77
2.12E − 26
DNA replication
61
2.41E − 18
DNA metabolic process
98
2.54E − 13
Mitotic sister chromatid segregation
18
1.73E − 07
Spindle organization
20
1.55E − 07
Cell cycle checkpoint
27
2.09E − 06
Regulation of cell cycle process
28
6.97E − 05
DNA repair
50
7.34E − 05
GO MF
Pyrophosphatase activity
91
0.00138
Adenyl ribonucleotide binding
152
0.00573
Guanyl ribonucleotide binding
44
0.0486
Threshold values: count ≥ 10 and Benjamini value < 0.01. The biological processes or pathways in common between SCEC and SCLC are in italics. BP = biological process; GO = gene ontology; MF = molecular function.
