IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

Figure 6

A schematic diagram depicting the proposed role of IL-1β signaling pathway in MSC migration. The process of cell migration is initiated by IL-1β-induced expression of MMP-1 in MSCs. The resultant increase of PAR1 activity causes cell migration.