Research Article

Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells

Table 1

Comparison of purity of MGE progenitors obtained in the three differentiation approaches.

ProtocolRDAdDNAdD
Purity (%)Purity (%)Purity (%)

Baseline56 ± 1.8956 ± 1.8164 ± 1.53
Stage 178 ± 3.4271 ± 2.5479 ± 2.16
Stage 276 ± 2.2975 ± 2.0065 ± 0.50

Baseline in the RD and AdD protocols represents treatment with SHH alone. Baseline in the NAdD protocol represents treatment with SB431542.