Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α

Figure 2

UC-MSC transplantation played a beneficial role in osteoporosis in CIA mice. (a–e) Micro-CT showed that the bone mineral density (BMD), trabecular bone volume/total volume (BV/TV), and trabecular number (Tb.N) of the femur were significantly decreased and trabecular separation (Tb.Sp) was significantly increased in CIA mice, compared with that in DBA/1 mice ( in each group). (f–i) The BMD (), trabecular BV/TV (), Tb.N, and Tb.Sp were partially improved in UC-MSC-treated CIA mice compared with control mice ( in each group). (j) H&E staining showed an increased Tb.N (arrow) in UC-MSC-treated CIA mice than in the control and ZA group (photographed at ×100). ; ; .

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