The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Figure 2

The gene and protein structure of IGF2BP2. Gene IGF2BP2 contains 16 exons at chromosome locus 3q27.2. The IGF2BP2 protein has six RNA-binding domains, including two N-terminal RRMs and four C-terminal KH domains. The p62 isoform has a 43-aa loss between the KH2 and KH3 domains due to the skipping of exon 10.