The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Figure 3

IGF2BPs regulate mRNA processing. IGF2BPs in the nucleus bind to the nascent mRNAs and join the assembly of messenger ribonucleoprotein (mRNP) complexes before exporting them to the cytoplasm. The mRNAs are then transported, in the form of mRNPs, along microtubules or other cytoskeletal structures to their destination in subcellular compartments. IGF2BPs maintain the stability of mRNAs and silence their translation during trafficking.