The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Figure 4

Regulation network of IGF2BP2. IGF2BP2 expression is controlled by HMGA2 which is a downstream target of Let-7 miRNA, and in return, IGF2BP2 binds to the Let-7 miRNA responsive elements and inhibits the Let-7 miRNA-mediated RNA degradation, independently of LIN28. HMGA1 suppresses expression of IGF2BP2, which in turn binds and stabilizes HMGA1 mRNA. After phosphorylation mediated by mTOR, IGF2BP2 promotes translation of IGF2 by internal ribosomal entry and consequently the downstream PI3K/Akt signaling. IGF2BP2 may also regulate the expression of other downstream effectors such as UCP1, NRAS, and LAMB2 as well as the relevant cellular functions.