Review Article
The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate
Table 1
Epigenetic regulation of osteogenic and adipogenic differentiation of AFSCs.
| Epigenetic changes | Effect of alteration | Finding | Reference |
| miR-125b | Overexpression during osteoblastic differentiation | Does not influence levels of Runx2, osteopontin, and ALPL gene expression | [92] | miR-21 | Overexpression during osteoblastic and adipogenic differentiation | Accelerates osteogenesis and decelerates adipogenesis | [70] | miR-302a and miR-Let7g | Upregulation of miR-302a and downregulation of miR-Let7g in AFSCs | Interact with Nanog and POUSF1 and are involved in adipogenesis and osteogenesis differentiation | [72] | H3K9ac, H4 hyperAc, H3K27me3, miR-17, and miR-148b | Upregulation of acetylation of H3K9 and H4, reduction of H3K27me3, and upregulation of miR-17 and miR-148b in osteogenic differentiation | Osteogenic differentiation is related to histone modifications and specific microRNA expression | [73] |
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