The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate

Table 1

Epigenetic regulation of osteogenic and adipogenic differentiation of AFSCs.

Epigenetic changes	Effect of alteration	Finding	Reference
miR-125b	Overexpression during osteoblastic differentiation	Does not influence levels of Runx2, osteopontin, and ALPL gene expression	[92]
miR-21	Overexpression during osteoblastic and adipogenic differentiation	Accelerates osteogenesis and decelerates adipogenesis	[70]
miR-302a and miR-Let7g	Upregulation of miR-302a and downregulation of miR-Let7g in AFSCs	Interact with Nanog and POUSF1 and are involved in adipogenesis and osteogenesis differentiation	[72]
H3K9ac, H4 hyperAc, H3K27me3, miR-17, and miR-148b	Upregulation of acetylation of H3K9 and H4, reduction of H3K27me3, and upregulation of miR-17 and miR-148b in osteogenic differentiation	Osteogenic differentiation is related to histone modifications and specific microRNA expression	[73]