The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate

Table 2

Associations between epigenetic modifications and diseased gestation condition.

Disease	Epigenetic marks	Alteration	Reference
Neural tube defects	Histone	(i) Myelomeningocele; (a) High levels of H3K4me2, H3K4me3, H3K27me2, and H3K27me3; (b) Low levels of KDM6B; (c) Decreased levels of H3K9ac, H3K18ac, and Gcn5.; (ii) Anencephalic; (a) increased levels of H3K27me3, H3K9Ac, H3K18Ac, and Gcn5.	[78]
Fetus-affected pregnancies	Global DNA methylation histone	Alterations in global DNA methylation, H4K16ac, H3K9ac, and H3K14ac and dysregulation of H3K9me2/me3 and H3K27me3	[80]
Down syndrome (DS)	MicroRNA	High levels of miR-125b-2, miR-155, and miR-3156 in pregnant women carrying fetuses with DS	[81]