Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges

Table 2

Experiences with drug interactions on skin cells.

Chemical name	Brand name	Toxicity	References
Fusidic acid, tetracycline, virginiamycin	Diverse	High toxicities at clinically applied doses	[72]
Gentamycin	Diverse	Favorable safety profile at low concentrations	[73, 83]
		Impaired cell migration and proliferation at higher concentrations (0.1 to 1.0 mg/mL), thus the clinically applied dose in topical preparations (about 0.1% or 1 mg/g) may impair cell function
Mafenide	Sulfamylon®	Cytotoxic even at lower local concentrations, therefore not suitable as a topical agent	[83]
Phenoxyethanol	Diverse	Promising alternative to antiseptic solutions	[72]
Polymyxin B	Diverse	Dose-dependent detrimental effects	[83]
Polymyxin B sulfate in combination with bacitracin	Polysporin®	Impaired proliferation at higher concentrations with the main effect being mediated by polymyxin B sulfate	[83]
Polymyxin B sulfate in combination with neomycin sulfate	Neosporin®	Much more favorable safety profile, containing far less polymyxin B but exerting excellent antimicrobiotic effects, discussed as a well-suited topical antibiotic	[83]
Povidone-iodine	Diverse	Toxicity depends on the presence of serum (higher without)	[72]