GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells

<div>Ganglioside pattern upon differentiation of hTSCs to either osteoblasts or adipocytes. (a) Metabolic radiolabeled gangliosides separated by HPTLC and visualized with a Beta-Imager 2000 (Biospace). Doubled spots in cellular gangliosides correspond to the presence of species with different chain lengths of fatty acids. The graph on the right represents the percentage distribution of radiolabeled gangliosides. (b) Real-time PCR analysis of GM1 synthase gene expression in hTSCs differentiated toward osteoblasts (O.D.) or adipocytes (A.D.) as compared to that in undifferentiated cells (T0). Ribosomal protein S14 gene was used as housekeeper gene. All data are means ± SD of three different experiments. 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Stem Cells International

fig1

Figure 1

Figure 1: GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells 