Research Article

Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling

Figure 2

(a) Sitagliptin treatment significantly improved endothelial regeneration compared to placebo treatment in both, Glp1r−/− (GLP) and C57Bl/6N wild-type (Bl6) mice. Additional treatment with the CXCR4 receptor blocker AMD3100 abolished the positive gliptin effect completely (n.s. = not significant; and ). (b) Evans blue staining of the injured carotid arteries three days after carotid injury (d0 = day 0; P = placebo; S = sitagliptin; AMD = AMD3100; and S & AMD = sitagliptin and AMD3100).
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