Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling

Figure 3

(a, b) The DPP4 inhibitor sitagliptin significantly enhanced the recruitment of CXCR4⁺CD133⁺ and CXCR4⁺Flk-1⁺ ciPC to the injured arterial walls. Additional administration of AMD3100 abolished the sitagliptin-mediated recruitment of ciPC (n.s. = not significant; ; and ≤ 0.01). (c, d) The different treatments had no effect on the proportion of ciPC in the uninjured arterial walls (n.s. = not significant). (e) Representative dot plots from the FACS analyses.

(a)

(b)

(c)

(d)

(e)