Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival

Table 1

Cox proportional hazards survival regression results of perfusion parameters and apparent diffusion coefficient (ADC) as continuous measures at all time points MRI#1, MRI#2, and MRI#3. Δ represents the relative change. Δ₃₂ = ln(MRI#3/MRI#2), and Δ₂₁ = ln(MRI#2/MRI#1).

Parameters	Statistics	MRI#1	MRI#2	MRI#3	Δ21	Δ32
	value					<0.01
	HR	NS	NS	NS	NS	20.67
	CI					[2.5,170.1]
	value		<0.05		<0.05	<0.01
	HR	NS	0.47	NS	0.17	17.08
	CI		[0.23, 0.98]		[0.03, 0.9]	[1.71, 171]
	value
	HR	NS	NS	NS	NS	NS
	CI
CE	value		<0.05			<0.05
	HR	NS	2.13	NS	NS	2.02
	CI		[1.01, 4.5]			[1.03, 3.98]
ADC	value
	HR	NS	NS	NS	NS	NS
	CI

Statistically significant. HR: hazard ratio; CI: 95% confidence interval; NS: not significant. value for Wald’s test.