Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

Figure 6

Expression of the stem cell marker, CD44, and the stem cell-related molecule, VEGF, in 13 GBM patients. (a) mRNA expression of CD44 in the tumor core and periphery was determined with qRT-PCR. The values are relative expression of mRNA normalized to the GAPDH. (b) Expression of CD44 represented by the P/C ratio. The P/C ratios for CD44 were calculated by dividing the amount of mRNA expression of CD44 in the tumor periphery by that in the core for each patient. (c) mRNA expression of VEGF in the tumor core and periphery. The expression and the level were determined as described for CD44. (d) Expression of VEGF represented by the P/C ratio. The P/C ratios for VEGF were determined as described for CD44.

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