Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Figure 2

Key signaling pathways and modifications of CSCs contributing to the resistance against chemotherapeutics. In order to survive during and after therapy, CSCs display many responses including EMT, self-renewal, tumor environment, quiescence, epigenetic modification, MDR, and so forth. The mechanisms by which CSCs contribute to resistance against therapeutics are summarized.