Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue

Figure 3

Self-renewal mechanisms of MSCs. (a) Self-renewal of stem cells is divided into two tasks, generation of daughter cells or differentiated cells. (b) Unfortunate accumulation of DNA damage, extrinsic force, and/or the changes of surrounding environment cause senescence and decline in functions of stem cells.

(a)

(b)