Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells

Figure 1

Two distinguished aspects of tumorigenicity and respective potential mechanisms. The tumorigenicity of iPSCs included two parts: one of them is teratoma formation and another is substantial tumor formation. The former is mostly attributed to epigenetic memory as well as inefficient purification, while the latter is ascribed to genomic instability and epigenetic changes.