Bioinformatics Analysis of Transcriptomic Data Reveals Refined Functional Networks for the Self-Renewal of Mouse Spermatogonial Stem Cells

Figure 1

SSC fate decisions and expression features of transcriptomics data. (a) SSCs are well-regulated in the niche to maintain their multipotency as well as the capacity for continuous spermatogenesis. (b) Comparison of genes expressed in primitive SG-A and SG-A. (c) Correlation between fold change and expression level for canonical markers. (d) The traditional strategy for identifying candidate genes based on statistical consideration only. (e) The proposed optimized strategy for identifying key genes considering both biological relevance and statistical optimizing.

(a)

(b)

(c)

(d)

(e)