Bioinformatics Analysis of Transcriptomic Data Reveals Refined Functional Networks for the Self-Renewal of Mouse Spermatogonial Stem Cells

Figure 3

The refined expression-function network. (a) Subnetwork for genes involved in cell proliferation or differentiation. (b) Subnetwork for genes associated with abnormal male infertility or spermatogenesis. (c) Subnetwork for Gfra1-centric relations (extended to two neighboring levels). Red or green color represents up- or downregulation in primitive SG-A. The inner circle size and the border width indicate the absolute and relative expression levels, respectively. (d) The detailed comparison of the biological relevance between the refined and traditional DE gene lists.