Transplantation of Human Amniotic Membrane over the Liver Surface Reduces Hepatic Fibrosis in a Cholestatic Model in Young Rats

Figure 3

Representative histological sections stained with sirius red from the three studied groups on the 2nd, 4th, and 6th postoperative weeks. In the SS group, no changes were noticed (a–c). In the BDL group, a progressive ductular reaction and periportal fibrosis were evident along the postoperative weeks (d–f). In the BDL + AM group, a progressive ductular reaction and periportal fibrosis were noted on the 2nd and 4th postoperative weeks (g and h). However, a marked reduction in liver fibrosis was evident on the 6th postoperative week (i). SS: sham surgery; BDL: bile duct ligature; BDL + AM: bile duct ligature plus amniotic membrane; PO: postoperative. Scale bar represents 200 μm.

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