Preconditioning by Hydrogen Peroxide Enhances Multiple Properties of Human Decidua Basalis Mesenchymal Stem/Multipotent Stromal Cells

Table 2

List of stress-related genes modulated in DBMSCs after exposure to H₂O₂.

(a) Upregulated genes in DBMSCs after preconditioning

Gene	Functions
ATOX1	Prosurvival, plays a significant role in carcinogenesis [52]
CYGB	Protective function during oxidative stress [45]
DHCR24	Proproliferative, protects neuronal cells from apoptotic cell death [53]
DUOX1	Proproliferative, plays a role in cellular migration [54]
DUOX2	Proproliferative, plays a role in esophageal, stomach, and colon cancer progression [48]
DUSP1	Involved in proliferation and differentiation in various human cancers [55]
FOXM1	Execution of mitosis, cell cycle progression, and other signal pathways leading to tumorigenesis [57]
GCLM	Plays antiapoptotic roles in ovarian follicles [56]
MBL2	Prosurvival, used for protection against oxidative stress in neurons [46]
OXR1	Plays a role in the etiology of glioma [51]
OXSR1	Prosurvival, protection against oxidative stress damage [47]
PRDX4	Oncogenic, highly expressed in a majority of human GBMs as well as in a mouse model of GBM [50]
TXNRD1	Overexpressed in many malignancies including lung cancer [49]

(b) Downregulated genes under preconditioning

Gene	Functions
APOE1	Leads to suppression of T cell proliferation [58]
BNIP3	Role in cell death [59]
EPX	Tumor suppressor [60]
FTH1	FTH1 can inhibit Daxx-mediated apoptosis [61]
GPX1	Deficiency causes increased migration and invasion of cells [62]
GPX3	Frequently deleted in prostate cancer [63]
PDLIM1	Deficiency causes increase in proinflammatory cytokines [64]
PRDX2	Silenced in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma [65]
PRNP	Role in cell proliferation, differentiation, death, and survival [66]