Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells

Table 1

Characteristics of the 1st transplantation.

Patient	Diagnosis	Gender/age	Donor	Conditioning regimen	Time to 2nd transplantation, days	Leucocytes, ×10^9/L at the time of the 2nd transplantation	Graft rejection
1 M	AML	m/23	Unrelated matched	MAC	50	0.01	Primary
2 P	MDS	f/56	Related matched	RIC	108	0.4	Primary
3 CH	MDS	f/40	Unrelated mismatched	RIC	83	0.04	Primary
4 F	AML	f/42	Unrelated matched	RIC	147	0.01	Secondary
5 IV	CMML	m/30	Unrelated matched	MAC	64	0.01	Primary
6 BU	AML	m/32	Unrelated mismatched	MAC	50	0.02	Primary
7 SA	AML	f/53	Unrelated mismatched	RIC	55	0.05	Primary
8 CHA	AML	f/32	Unrelated mismatched	MAC	45	0.02	Primary

AML: acute myeloid leukemia; MDS: myelodysplastic syndrome; CMML: chronic myelomonocytic leukemia; RIC: reduced intensity conditioning (fludarabine phosphate (30 mg/m²/day for 6 days) combined with busulfan 4 mg/kg/day for 2 days and antithymocitic globulin 10 mg/kg/day for 4 days); MAC: myeloablative conditioning (cyclophosphamide 60 mg/kg/day for 2 days combined with busulfan 4 mg/kg/day for 4 days).