Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/<i>β</i>-Catenin Signaling Pathway

<div>Schematic diagram of enhancing effect of calcium on adipogenic differentiation of hUCB-MSCs. The adipogenic differentiation of hUCB-MSCs is induced by decreased canonical Wnt5a/<i>β</i>-catenin signaling. Calcium accelerated the reduction of Wnt5a and <i>β</i>-catenin proteins during adipogenic induction, which resulted in significantly decreased Wnt5a/<i>β</i>-catenin signaling. Consequently, the exogenous calcium treatment enhanced the adipogenic differentiation via negatively regulating the Wnt5a/<i>β</i>-catenin signaling.</div>

Stem Cells International

fig7

Figure 7

Figure 7: Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/<i>β</i>-Catenin Signaling Pathway 

Figure 7 | Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/β-Catenin Signaling Pathway 