TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

Figure 6

Molecular phenotype of CYD-treated hMSCs. (a) Hierarchical clustering of genes that were differentially expressed in CYD-treated and untreated control (CNT) hMSCs. Rows represent individual gene expression for duplicate treated and untreated samples, as indicated. Columns represent individual transcripts. Relative expression levels are presented colorimetrically, according to the scale shown in the color bar. (b) Pie chart showing the pathways with the highest enrichment of genes significantly upregulated in CYD-treated cells. (c) Venn diagram depicting the overlap between the upregulated genes in TGFβ1-treated cells (UP TGFβ1 versus CNT) and the downregulated genes in CYD-treated cells (DOWN CYD versus CNT).

(a)

(b)

(c)