Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction

Table 3

Drug/cytokine pretreatment in MSC transplantation for treating MI.

Drug/cytokine	Disease	Model	Dose/method	Function	Reference
Pioglitazone	MI	Rat	3 mg/kg/day/2 weeks	Cardiac function ↑	[90]
Atorvastatin	MI	Rat	1 mM/24 h	Neovascularization ↑	[91]
Sevoflurane	MI	Rat	3%/30 min	Activation of CSCs	[16]
Tadalafil	MI	Rat	1 μmol/L/2 h	Survival ↑; homing ↑	[92]
AER-ME	MI	Rat	200 mg/kg/day/30 days	Viability ↑; differentiation ↑	[93]
SRT1720	MI	Rat	0.5 μM/24 h	Survival ↑	[94]
Angiotensin II	MI	Rat	100 nM/24 h	Infarct size ↓	[95]
Salvianolic acid B	MI	Rat	10 μM/30 min	Infarct size ↓	[96]
DNP	MI	Rat	0.25 mM/20 min	Infarct size ↓; angiogenesis ↑	[97]
Edaravone	MI	Rat	500 μM	Apoptosis ↓; migration ↑	[98]
Trimetazidine	MI	Rat	2.08 mg/kg/day	Apoptosis ↓;infarct size ↓	[99]
IGF-1	MI	Rat	10 ng/mL/48 h	Survival ↑; apoptosis ↓	[100]
IL-1β, TNF-α	MI	Rat	10 ng/mL/24 h	Infarct size ↓	[101]
(EGb) 761	MI	Rat	100 mg/kg/day	Antioxidant ↑; differentiation ↑	[102]
Tβ4	MI	Rat	1 μg/mL/48 h	Proliferation ↑; retention ↑; survival ↑	[103]
Tanshinone IIA	MI	Rat	0.2 μg/mL/72 h	Migration ↑	[104]
Astragaloside IV	MI	Rat	0.4 μg/mL/72 h	Migration ↑	[104]
Melatonin	MI	Mouse	5 mM/24 h	Infarct size ↓	[105]
Apicidin	MI	Mouse	3 μM/24 h	Cardiac markers ↑	[106]
H2O2	MI	Mouse	200 μmol/L/2 h	Apoptosis ↓; angiogenesis ↑	[50]
PMSNs-siCCR2	MI	Mouse	25 μg/g/cotransplantation	Survival ↑; angiogenesis ↑	[107]
Aliskiren	MI	Mouse	15 mg/kg/day	Survival ↑; systolic function ↑	[108]
Atorvastatin	MI	Porcine	0.25 mg/kg/day	Infarct size ↓	[109]
TG-0054	MI	Porcine	2.85 mg/kg/day	LV contractility ↑	[110]
GLP-1	MI	Porcine	100 nM/48 h	Apoptosis ↓; infarct size ↓	[111]
G-CSF	MI	Rabbit	20 u/kg/day	Apoptosis ↓	[112]
Atorvastatin	MI	Rabbit	1.5 mg/kg/day	Myocardial remodeling ↓	[113]
Nicorandil	—	MSC culture	100 μM/1.5 h	Apoptosis ↓	[114]
Geraniin	—	MSC culture	20 μM/24 h	Efficacy ↑	[115]
Exendin-4	—	MSC culture	0–20 nm/L/12 h	Proliferation ↑	[116]

DNP: 2,4-dinitrophenol; GLP-1 :glucagon-like peptide-1; DMOG: dimethyloxalyl glycine; AER-ME: Ailanthus excelsa Roxb. methanolic extract; PMSNs: siRNA-loaded photoluminescent mesoporous silicon nanoparticles. TG-0054: a novel CXCR4 antagonist; EGb 761: Ginkgo biloba extract; G-CSF: granulocyte colony-stimulating factor; Tβ4: thymosin β4.