Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study

Figure 4

Photomicrographs of histological sections stained with toluidine blue taken from the TCP group (a–c). (a) The defect area was still evident 12 weeks after surgery. Connective tissue and adipose bone marrow were generated at the injured area (scale bar: 1000 μm). (b) The remaining TCP material was not fully osteointegrated () (scale bar: 500 μm). (c) Scarce trabecular bone formation in association with TCP granules. Nonosteointegrated TCP granules () were surrounded by connective tissue (red circle) or adipose bone marrow (red plus sign) (scale bar: 500 μm).