Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study

Figure 6

Photomicrographs of histological sections stained with toluidine blue taken from the hMSC-TCP group (a–c). (a) Almost complete bone defect regeneration (scale bar: 1000 μm). (b) Newly formed bone showed disorganized and anastomosed trabeculae. TCP granules were osteointegrated (scale bar: 500 μm). (c) TCP granules were surrounded by newly formed trabecular bone (B). Not completely osteointegrated TCP granules () were in contact with adipose bone marrow (red plus sign) or connective tissue (red circle) at their bone-free surface. Normal osteocytes were present at the regenerated trabecular bone (scale bar: 500 μm).