Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats

Figure 2

Effects of hUC-MSC transplantation on the survival rates and liver function in ALF rats. A total of 36 rats were randomly divided into three groups: P5 hUC-MSCs group, P10 hUC-MSCs group, and NS group ( per group). D-GalN/LPS were administered to rats intraperitoneally to induce ALF. 24 h later, the P5 hUC-MSCs and P10 hUC-MSCs (dose: 1.0 × 10⁷ cells/kg/mL) were transplanted, respectively, while the NS group was given 1 mL normal saline. The blood samples were collected at 0 h, 24 h, 48 h, and 72 h post-D-GaIN/LPS injection. (a) The survival rate in the P5 hUC-MSCs, P10 hUC-MSCs, and NS groups. Levels of serum (b) alanine transferase (ALT), (c) aspartate aminotransferase (AST), and (d) total bilirubin (TBil) in treatment of ALF rats. Data were expressed as mean ± SD. , , . hUC-MSCs, human umbilical cord-derived mesenchymal stem cells; D-GalN, D-galactosamine; LPS, lipopolysaccharide.

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