New Strategies and In Vivo Monitoring Methods for Stem Cell-Based Anticancer Therapies

Table 1

Current clinical trials using stem cell-based therapies for anticancer treatment in the US.

Title	NCT number	Status	Sponsors	Enrollment	Funding	Start	Location
Generation of Cancer Antigen-Specific T-cells From Human Induced Pluripotent Stem Cells (iPSC) for Research and Potential Future Therapy	NCT03407040	Enrolling by invitation	National Cancer Institute (NCI), National Institutes of Health Clinical Center (CC)	7000	NIH	30 Jan. 18	National Institutes of Health Clinical Center, Bethesda
Stem Cells in NF1 Patients with Tumors of the Central Nervous System	NCT03332030	Recruiting	Children’s Research Institute	20	Other	27 Nov. 15	Children’s National Medical Center, Washington
Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma	NCT03072134	Recruiting	Northwestern University	36	Other	24 Apr. 17	Northwestern Memorial Hospital, Chicago
Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies	NCT03056339	Recruiting	MD Anderson Cancer Center	36	Other	21 Jun. 17	University of Texas MD Anderson Cancer Center, Houston
Mesenchymal Stem Cells (MSC) for Ovarian Cancer	NCT02530047	Active, not recruiting	MD Anderson Cancer Center	5	Other	16 May 16	University of Texas MD Anderson Cancer Center, Houston
MV-NIS Infected Mesenchymal Stem Cells in Treating Patients with Recurrent Ovarian Cancer	NCT02068794	Recruiting	Mayo Clinic, National Cancer Institute (NCI)	54	Other, NIH	Mar. 14	Mayo Clinic, Rochester
Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients with Recurrent High-Grade Gliomas	NCT02015819	Active, not recruiting	City of Hope Medical Center, National Cancer Institute (NCI)	18	Other, NIH	7 Oct. 14	City of Hope Medical Center, Duarte
Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer	NCT01983709	Terminated	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	7	Other	Oct. 13	Johns Hopkins Hospital, Baltimore
Stem Cell Transplantation as Immunotherapy for Hematologic Malignancies	NCT00143559	Completed	St. Jude Children’s Research Hospital	17	Other	Aug. 05	St. Jude Children’s Research Hospital, Memphis

Data was obtained from NIH clinicaltrials.gov by performing searches for cancer-related clinical trials using the following terms: stem cell-based anticancer vaccine, engineered stem cells, targeted stem cell therapy, stem cell virus carrier, stem cell nanoparticle carrier, and stem cell immunotherapy.