Angiotensin II Attenuates the Bioactivities of Human Endothelial Progenitor Cells via Downregulation of β2-Adrenergic Receptor

Figure 4

The interaction between AT1R and ADRB2 is attenuated by Ang II. (a) Association between AT1R and ADRB2 in EPCs was confirmed by immunoprecipitation assay. For endogenous IP, lysate from EPCs was immunoprecipitated using a specific antibody, anti-AT1R, followed by detection with ADRB2 antibody. (b) To confirm the role of Ang II in the interaction between AT1R and ADRB2, EPCs were treated with Ang II or TERT. (c) Proposed working model for the role of ADRB2 in Ang II-induced EPC bioactivities.

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