Mesenchymal Stem Cells Enhance Liver Regeneration via Improving Lipid Accumulation and Hippo Signaling

Figure 1

Effects of MSCs on LR after PHx. (a) The ratio of the remaining liver weight to total body weight (LW/BW) at 24 h, 48 h, and 7 days after PHx in rats (). (b) The expression of PCNA by Western blot in each group at 24 h, 48 h, and 7days after PHx. (c) Immunohistochemical staining of ki-67 in the liver specimens of each group at 24 h, 48 h, and 7 days after PHx. (d) Percentage of ki-67-positive cells in each group at 24 h, 48 h, and 7 days after PHx (). (e) RT-qPCR analysis showed the expression of genes related to mitosis (CCNA, CCNB, CCND, and CCNE) (). (f) & (g) H&E staining of liver specimens of each group at 24 h, 48 h, and 7 days after PHx and the number of mitotic hepatocytes on each group (). (h) Immunohistochemical staining of β-catenin in order to show the hepatocyte membrane and count the number of cells (). Values represent mean ± SD. ; ; .

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