Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction

Table 1

Treatment effect on left ventricular (LV) function by cardiac MRI.

Group	Sham	Control	ASCs in saline	ASCs in alginate hydrogel
LV function (LVEF and LVESV) by cardiac MRI
LVEF (%)
Day 1	60.84 ± 2.21	42.64 ± 11.66	42.60 ± 5.98	45.04 ± 9.08
Day 14	61.12 ± 0.94	43.24 ± 11.05	50.32 ± 4.34	50.91 ± 4.76
Day 28	61.08 ± 1.83	43.85 ± 10.68	49.48 ± 3.75	50.75 ± 7.28
ΔLVEF 14 days	0.28 ± 1.80	1.73 ± 4.90	6.99 ± 6.26	4.81 ± 4.89
ΔLVEF 28 days	0.24 ± 1.97	1.21 ± 3.77	6.89 ± 4.67	5.71 ± 4.48
LVESV (ml)
Day 1	0.12 ± 0.02	0.19 ± 0.04	0.17 ± 0.04	0.17 ± 0.05
Day 14	0.14 ± 0.04	0.23 ± 0.07	0.21 ± 0.06	0.17 ± 0.02
Day 28	0.16 ± 0.04	0.25 ± 0.07	0.22 ± 0.06	0.20 ± 0.05
ΔLVESV 14 days	0.02 ± 0.02	0.04 ± 0.04	0.05 ± 0.04	0.01 ± 0.02
ΔLVESV 28 days	0.04 ± 0.03	0.06 ± 0.05	0.05 ± 0.04	0.03 ± 0.02
Number of animals
Data without LVEF > 50% at day 1 in infarct groups
LVEF (%)
Day 1	60.84 ± 2.21	36.62 ± 9.17	41.57 ± 5.32	41.07 ± 8.09
Day 14	61.12 ± 0.94	38.83 ± 8.80	49.13 ± 3.28	48.64 ± 4.02
Day 28	61.08 ± 1.83	38.34 ± 8.43	48.72 ± 3.06	49.08 ± 8.13
ΔLVEF 14 days	0.28 ± 1.80	2.21 ± 5.70	7.22 ± 6.83	7.79 ± 2.91
ΔLVEF 28 days	0.24 ± 1.97	1.71 ± 4.59	7.15 ± 4.87	8.02 ± 2.30
LVESV (ml)
Day 1	0.12 ± 0.02	0.21 ± 0.03	0.18 ± 0.04	0.19 ± 0.04
Day 14	0.14 ± 0.04	0.25 ± 0.03	0.22 ± 0.06	0.18 ± 0.02
Day 28	0.16 ± 0.04	0.28 ± 0.07	0.23 ± 0.05	0.22 ± 0.06
ΔLVESV 14 days	0.02 ± 0.02	0.04 ± 0.05	0.05 ± 0.05	0.00 ± 0.02
ΔLVESV 28 days	0.04 ± 0.03	0.07 ± 0.05	0.05 ± 0.04	0.03 ± 0.02
Number of animals

ASC: adipose-derived stromal cells; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume.