Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats

Figure 7

qPCR analysis shows changes in relative gene expression of apoptotic genes (p53 and Bax), antiapoptotic gene (Bcl2), EMT-related gene (TGFβ1), inflammation-related gene (NFκB), angiogenesis-related genes (VEGF), and metastasis-related genes (MMP9 and TIMP1) in livers of normal rats (Nor) and DEN-induced HCC rats treated by PBS or exosomes derived from CSCs (CSC-Ex) or MSCs (MSC-Ex). Data presented as fold change from the normal (Nor) control group. Values are expressed as fold change (). Different letters on columns mean significant difference. , , , and versus PBS group; versus CSC group.

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