Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells

Table 1

Meniscus scoring system for the evaluation of meniscus repair tissue [23, 24].

	0	1	2	3
Defect-filling	No fill	<25%	25–75%	>75%
Surface	No surface	Ruptured	Fissured/fibrillated	Meniscus-like
Integration	No integration	Partial, unilateral integration	Bilateral partial or unilateral complete integration	Bilateral complete integration
Cellularity	No cells	>10 cell cluster/slide	No cell cluster/slide, cell-ECM	Meniscus-like cell-ECM ratio
Cell morphology	No cells	<25% meniscus-like cells	25–75% meniscus-like cells	>75% meniscus-like cells
Content of proteoglycan	No staining for proteoglycan	<25%	25–75%	>75%
Content of collagen II	No staining for collagen II	<25%	25–75%	>75%
Stability	No stability	Weak	Stable in shape	Stable to pressure and pulling stress

ECM = extracellular matrix.