Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine

Table 6

Preclinical studies with MSCs.

Cell source	Cell type	Pathology	Outcome	Reference
Rat	Human AD-MSC	Peripheral nerve injury	Repair of nerve	[119]
Rat	Human AD-MSC	Cerebral ischemia	Repair of nerve	[120]
Mouse	Human UCB-MSC	Hind limb ischemia	Repair of artery	[121]
Rat	Human UCB-MSC	Cavernosal nerve injury	Improved function	[122]
Rat	Allogenic AD-MSC	Peripheral nerve injury	Repair of nerve	[123]
Rat	Allogenic BM-MSC	Skin wound	Repair of skin	[124]
Rat	Autologous BM-MSC	Spinal cord injury	Repair of nerve	[125]
Rat	Autologous AD-MSC	Spinal cord injury	Repair of nerve	[126]
Rat	Mouse SC-MSC	Erectile dysfunction	Improved function	[127]
Rabbit	Human AD-MSC	Spinal cord injury	Repair of nerve	[128]
Rabbit	Human UCWJ-MSC	Normal	No immune rejection	[129]
Rabbit	Porcine S-MSC	Osteochondral defect	Immune rejection	[130]
Rabbit	Allogenic S-MSC	Articular cartilage defect	Repair of defect	[131]
Rabbit	Allogenic BM-MSC	Articular cartilage defect	Repair of defect	[132]
Rabbit	Allogenic/autologous BM-MSC	Bone defect	Repair of defect	[133]
Porcine	Autologous BM-MSC	Articular cartilage defect	Repair of defect	[134]
Porcine	Mouse BM-CMSC	Vocal fold wound	Repair of vocal fold	[135]
Porcine	Allogenic S-MSC	Articular cartilage defect	Repair of defect	[136]
Canine	Allogenic BM-MSC	Bone defect	Repair of defect	[137]
Canine	Allogenic BM-MSC	Cardiac ischemia	Improved function	[138]
Canine	Allogenic BM-MSC	Myocardial infarction	Improved function	[139]
Canine	Allogenic BM-MSC	Skin wound	Repair of skin	[140]
Canine	Allogenic BM-MSC	Normal	Inflammation, tubular necrosis, mineralization, and fibrosis of kidney	[141]
Canine	Allogenic AD-MSC	Spinal cord injury	Repair of nerve	[80]
Canine	Allogenic UCB-MSC	Spinal cord injury	Repair of nerve	[84]
Canine	Autologous BM-MSC	Disc degeneration	Repair of nerve	[142, 143]
Canine	Autologous BM-MSC	Bone defect	Repair of defect	[144]
Canine	Autologous BM-MSC	Static nerve injury	Repair of nerve	[145]
Canine	Autologous BM-MSC	Osteochondral defect	Repair of defect	[146]
Canine	Autologous BM-MSC	Myocardial infarction	Improved function	[147]
Canine	Autologous BM-MSC	Osteonecrosis of the femoral head	Repair of blood vessel	[148]
Canine	Autologous BM-MSC	Oral ulcer	Repair of ulcer	[149]
Canine	Autologous BM-MSC	Diabetes	Improved function	[150]
Canine	Autologous BM-MSC	Vocal fold wound	Repair of vocal fold	[151, 152]
Canine	Autologous BM-MSC	Periodontal defect	Repair of defect	[153]
Canine	Autologous BM-MSC	Periodontal class II furcation defect	Repair of defect	[154]
Canine	Allogenic/autologous BM-MSC	Spinal cord injury	Repair of nerve	[155]
Canine	Autologous AD-MSC	Spinal cord injury	Repair of nerve	[156]
Canine	Autologous MSC	Chondral defect	Repair of defect	[157]
Canine	Allogenic AD-MSC	Thoracolumbar intervertebral disc disease	Improved clinical sign	[158]
Equine	Allogenic AD-MSC	Superficial digital flexor tendonitis	Repair of tendonitis	[159]
Equine	Autologous BM-MSC	Superficial digital flexor tendonitis	Repair of tendonitis	[160]
Equine	Autologous BM-MSC	Osteoarthritis	Repair of osteoarthritis	[161]
Equine	Allogenic/autologous BM-MSC	Normal	Enhancement of MSC	[162]
Dolphin	Autologous AD-MSC	Normal	Cell collection success	[163]
Caprine	Autologous BM-MSC	Osteoarthritis	Repair of osteoarthritis	[164]

AT-MSC: adipose tissue-derived mesenchymal stem cells; UCB-MSC: umbilical cord blood-derived mesenchymal stem cells; BM-MSC: bone marrow-derived mesenchymal stem cells; SC-MSC: skeletal muscle-derived mesenchymal stem cells; S-MSC: synovium-derived mesenchymal stem cells; UCWJ-MSC: umbilical cord Wharton’s jelly-derived mesenchymal stem cells.