SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction

Figure 4

SHP2 plays a key role in NSC proliferation, differentiation, and migration. During NSC proliferation, several essential signaling branches, such as FGF/FGFR and VEGF/VEGFR, transmit the signal to adaptor proteins, for example, Grb2, and subsequently activate SHP2 as well as ERK pathway. Cell cycle-associated genes are considered as the target genes, for example, Bmi-1 is responsible for SHP2-mediated NSC proliferation. Besides, for NSC differentiation, it seems like SHP2 either regulates neurogenesis via ERK signaling or promotes astrogliogenesis through STAT3 signaling. On the other hand, SDF1/CXCR4 is responsible for migration of NSCs and their progenitors.