Review Article
SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction
Table 1
Similarities and differences between SHP2 signaling in different stem cells.
| | SHP2-ERK signaling | SHP2-STAT signaling | SHP2-P38 signaling | SHP2-C-jun signaling | SHP2-AKT signaling |
| ESCs | Ectoderm and/or endoderm lineage differentiation | Self-renewal | Mesoderm lineage differentiation | Not determined | Not determined | HSCs | Self-renewal | Proliferation | Not determined | Monocytic differentiation | Proliferation | MSCs | Chondrogenic differentiation | Not determined | Not determined | Not determined | Proliferation and osteogenic differentiation | NSCs | Proliferation and/or neuron differentiation | Astrocyte differentiation | Not determined | Not determined | Not determined | CSCs | Self-renewal and differentiation | Not determined | Not determined | Proliferation | Not determined |
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