The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives

Table 1

Comparison of stem cells for nervous system disorders.

Category	Source	Advantages	Disadvantages	Ref.
Embryonic stem cells	Embryonic tissues or developing nervous system	Pluripotency, nonimmunogenic	Insufficient sources, ethical problems, possible tumorigenesis	[11, 12]
Induced pluripotent stem cells	Somatic cells	Pluripotency, no ethical problems, sufficient sources	Unstable induction, possible infection	[11, 13]
Adult neural stem cells	Adult neural tissue	Multipotency, no ethical problems	Insufficient sources, hard acquisition, purified problems	[11, 14]
SKPs	Dermis	Multipotency, no ethical problems, sufficient sources, easy acquisition	Relatively low neurogenic cells, purified problems	[15, 16]
Mesenchymal stem cells	Including bone marrow, adipose tissue	Multipotency, no ethical problems, sufficient sources	Relatively low neurogenic cells, purified problems, relatively hard acquisition	[11, 17]