Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity

Table 1

Soluble factors from MSCs.

Cytokines	Chemokines
IL-1α	CCL1
IL-1β	CCL2
IL-2	CCL5
IL-3	CCL8
IL-6	CCL11
IL-7	CCL15
IL-10	CCL16
IL-11	CCL18
IL-12	CCL22
IL-13	CCL23
IL-16	CCL24
IFN-γ	CCL26
TNF-α	CXCL1
LIF	CXCL2
TGF-β	CXCL3
MIF	CXCL5
OSM	CXCL6
G-CSF	CXCL8
M-CSF	CXCL11
GM-CSF	CXCL12
FLT3LG	CXCL13
SCF	CX3CL1
Thrombopoietin	XCL1
TSG-6
	Other factors
Angiogenic factors	CXCR3
Angiogenin	PGE2
Angiopoietin	PAI-1
VEGF	MMP1
	MMP3
Growth factors	MMP9
HGF	MMP10
EGF	MMP13
IGF-1	TIMP-1
FGF-2	TIMP-2
FGF-4	TIMP-3
FGF-7	TIMP-4
FGF-9	Leptin
BMP-7	IGFBP-1
BDGF	IGFBP-2
GDNF	IGFBP-3
NGF	IGFBP-4
PIGF	Adiponectin
PDGF	Adrenomedullin
	Osteoprotegerin

IL: interleukin; IFN: interferon; TNF: tumor necrosis factor; LIF: leukemia inhibitory factor; TGF: transforming growth factor; MIF: macrophage migration inhibitory factor; OSM: oncostatin M; G-CSF: granulocyte colony-stimulating factor; M-CSF: macrophage colony-stimulating factor; GM-CSF: granulocyte macrophage colony-stimulating factor; FLT3LG: Fms-related tyrosine kinase 3 ligand; SCF: stem cell factor; TSG-6: TNF-stimulated gene 6; VEGF: vascular endothelial growth factors; HGF: hepatocyte growth factor; EGF: epidermal growth factor; IGF: insulin-like growth factor; FGF: fibroblast growth factor; BMP: bone morphogenetic protein; BDNF: brain-derived neurotrophic factor; GDNF: glial cell-derived neurotrophic factor; NGF: nerve growth factor; PIGF: placenta growth factor; PDGF: platelet-derived growth factor; CCL: C-C motif chemokine ligand; CXCL: C-X-C motif chemokine ligand; CX3CL: C-X3-C motif chemokine ligand; XCL: X-C motif chemokine ligand; CXCR: C-X-C motif chemokine receptor; PGE2; prostaglandin E2; PAI: plasminogen activator inhibitor; MMP: matric metalloproteinase; TIMP: tissue inhibitor of metalloproteinase; IGFBP: insulin-like growth factor-binding protein.