Review Article
Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
Figure 2
HAT regulate cancer stem cells through different mechanisms. HAT promote a cancer stem cell phenotype by inducing chromatin modifications (a), acting as a transcriptional coactivator (b) or acetylating cancer stem cell transcription factors (c). HAT can also constitute chimeric proteins as a result of chromosome translocation (d), which possess aberrant HAT activities.
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